Giraffe genome sequence reveals clues to its unique morphology and physiology

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dc.contributor.author Agaba, Morris
dc.contributor.author Ishengoma, Edson
dc.contributor.author Miller, Webb C.
dc.contributor.author McGrath, Barbara C.
dc.contributor.author Hudson, Chelsea N.
dc.contributor.author Bedoya Reina, Oscar C.
dc.contributor.author Ratan, Aakrosh
dc.contributor.author Burhans, Rico
dc.contributor.author Chikhi, Rayan
dc.contributor.author Medvedev, Paul
dc.contributor.author Praul, Craig A.
dc.contributor.author Wu-Cavener, Lan
dc.contributor.author Wood, Brendan
dc.contributor.author Robertson, Heather
dc.contributor.author Penfold, Linda
dc.contributor.author Cavener, Douglas R.
dc.date.accessioned 2019-05-27T06:09:42Z
dc.date.available 2019-05-27T06:09:42Z
dc.date.issued 2016-05-16
dc.identifier.uri DOI: 10.1038/ncomms11519
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/212
dc.description Research Article published by Nature Communications en_US
dc.description.abstract The origins of giraffe’s imposing stature and associated cardiovascular adaptations are unknown. Okapi, which lacks these unique features, is giraffe’s closest relative and provides a useful comparison, to identify genetic variation underlying giraffe’s long neck and cardiovascular system. The genomes of giraffe and okapi were sequenced, and through comparative analyses genes and pathways were identified that exhibit unique genetic changes and likely contribute to giraffe’s unique features. Some of these genes are in the HOX, NOTCH and FGF signalling pathways, which regulate both skeletal and cardiovascular development, suggesting that giraffe’s stature and cardiovascular adaptations evolved in parallel through changes in a small number of genes. Mitochondrial metabolism and volatile fatty acids transport genes are also evolutionarily diverged in giraffe and may be related to its unusual diet that includes toxic plants. Unexpectedly, substantial evolutionary changes have occurred in giraffe and okapi in double-strand break repair and centrosome functions. en_US
dc.language.iso en_US en_US
dc.publisher Nature Communications en_US
dc.subject Research Subject Categories::NATURAL SCIENCES en_US
dc.title Giraffe genome sequence reveals clues to its unique morphology and physiology en_US
dc.type Article en_US

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