Acute and Subacute Oral Toxicity Evaluation of Commiphora Campestris Methanolic Stem Bark Extract (CASBMCE) In Mice and Rats

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dc.contributor.author Chacha, Musa
dc.contributor.author Nyunza, Furaha
dc.contributor.author Makule, Edna E.
dc.date.accessioned 2019-05-23T07:41:35Z
dc.date.available 2019-05-23T07:41:35Z
dc.date.issued 2017-11-16
dc.identifier.uri DOI: 10.19080/JCMAH.2017.04.555629
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/171
dc.description Research Article published by Juniper Publishers Volume 4 Issue 1 -November 2017 en_US
dc.description.abstract This study was done to evaluate the acute and sub acute toxicity of Camiphora campestris Methanolic Stem Bark Extract (CASBMCE). In acute toxicity tests four groups of mice (n=5/group/sex) were orally treated with doses of 300,600 and 1200mg/kg and clinical manifestation, body weight and mortality was recorded for 14 days. In sub acute toxicity study rats received CASBMCE by gavages’ at doses 150mg/kg, 200mg/kg and 250mg/kg (n=5 rats/group/sex) for 28 days and body weight, relative organ weight, biochemical, hematological and histopathological changes in vital organs were determined. In acute toxicity study mice showed signs of behavioral changes and resumed to their normal bright status. Death was recorded at a dose of 600 and 1200mg/kg. In sub acute tests no mortality was recorded animals were bright and normal. CASBMCE increased the levels of the liver enzymes (AST & ALT) with increasing doses. Biochemical examination showed differences between CASBMCE tested and control group. Hematology showed significant differences in CASBMCE tested parameters compared to control group. CASBMCE showed toxicity in the body tissues, in high sub acute doses. This study concludes that acute toxicity study CASBMCE, produced mortality in males and females at a dose of 600mg/kg and 1200mg/kg. In sub acute doses CASBMCE, produced no mortality. Major effects were rise of glucose levels, decreased vital organs size, and thickened female lung alveolar walls that probably increased RBC counts. CASBMCE reduced cholesterol levels indicating antilipidemic effect. More research to validate safety doses in humans is still needed.. en_US
dc.language.iso en_US en_US
dc.publisher Juniper Publishers en_US
dc.subject Commiphora campestris en_US
dc.subject Acute toxicity en_US
dc.subject Sub acute toxicity en_US
dc.subject Dimethyl sulphoxide (DSMO) en_US
dc.title Acute and Subacute Oral Toxicity Evaluation of Commiphora Campestris Methanolic Stem Bark Extract (CASBMCE) In Mice and Rats en_US
dc.type Article en_US

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