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A systematic review of antibiotic-resistant Escherichia coli and Salmonella data obtained from Tanzanian healthcare settings (2004-2014)

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dc.contributor.author Mwanyika, Gaspary O.
dc.contributor.author Subbiah, Murugan
dc.contributor.author Buza, Joram
dc.contributor.author Rugumisa, Bernadether T.
dc.contributor.author Call, Douglas R.
dc.date.accessioned 2019-05-23T06:27:18Z
dc.date.available 2019-05-23T06:27:18Z
dc.date.issued 2017-01-14
dc.identifier.issn 1996-0808
dc.identifier.uri DOI: 10.5897/AJMR2016.8282
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/163
dc.description Research Article published by African Journal of Microbiology Research Vol. 11(2), 14 January 2017 en_US
dc.description.abstract Antibiotic-resistant Escherichia coli and Salmonella are an increasing challenge to global health. In Tanzania reliable data is limited for trends of resistance in major hospital-acquired pathogens. Data on the prevalence of antibiotic-resistant E. coli and Salmonella from Tanzanian sources (2004-2014) was extracted from PubMed and Google Scholar databases (April -June, 2015). Descriptive statistics and logistic-regression analysis were used to estimate the prevalence and trends for resistant E. coli and Salmonella to selected antibiotics using R software. A total of 24 articles were availablefor review, of which 21/24 (87.5%) and 7/24 (29.2%) reported the prevalence of antibiotic-resistant E. coli and Salmonella, respectively. Across all studies the average prevalence of resistance to ampicillin and cotrimoxazole was higher for E. coli (81.6 and 77.7%, respectively) than for Salmonella (64.7and 59.3%, respectively). Both groups of pathogens were also resistant to ciprofloxacin (20-22%) and 3rd- generation cephalosporins (2.5-27.8%). A logistic-regression model for published data (2004-2014) indicated that during this period of time there has been a significant increase to amoxicillin/clavulanate, ceftazidime, ciprofloxacin and gentamicin in E. coli (P< 0.001), and a significant increase in resistance to ampicillin for Salmonella (P < 0.05).Decreased E. coli and Salmonella susceptibility to critical antibiotics threatens the effective treatment of these infections in Tanzania. Proactive strategies are needed to preserve these antibiotics that remain largely active against bacterial pathogens in Tanzania. en_US
dc.language.iso en_US en_US
dc.publisher African Journal of Microbiology Research en_US
dc.subject Antibiotic resistance en_US
dc.subject nosocomial E. coli en_US
dc.title A systematic review of antibiotic-resistant Escherichia coli and Salmonella data obtained from Tanzanian healthcare settings (2004-2014) en_US
dc.type Article en_US


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