Browsing by Author "Vianney, John-Mary"
Now showing items 1-20 of 25
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A case-control study on the driving factors of childhood brain volume loss: What pediatricians must explore
(PLOS ONE, 2022-12-30)Background The brain volume loss also known as brain atrophy is increasingly observed among children in the course of performing neuroimaging using CT scan and MRI brains. While severe forms of brain volume loss are ... -
Cholinergic neurons regulate secretion of glial cell line-derived neurotrophic factor by skeletal muscle cells in culture.
(Elsevier, 2011-05-16)Glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent survival factor for both central and peripheral neurons. GDNF has been shown to be a potent survival factor for motor neurons during ... -
Computational analysis of Urolithin A as a potential compound for anti-inflammatory, antioxidant, and neurodegenerative pathways
(Elsevier, 2025-02-01)Urolithin A, an active precursor derived from the metabolism of ellagitanins in rats and humans, is known for its potential health benefits, including stimulating mitophagy and promoting muscular skeletal function. While ... -
Detection of Rift Valley Fever Virus Interepidemic Activity in Lower Moshi area of Kilimanjaro Region, North Eastern Tanzania: A Community Survey
(Research Square, 2021-01-22)Background: Rift Valley fever virus (RVFV) is a zoonotic arbovirus of public health impact infecting livestock, wildlife, and humans mainly in Africa and other parts of the world. Despite its public health importance, ... -
Effects of acetylcholine and electrical stimulation on glial cell line-derived neurotrophic factor production in skeletal muscle cells
(Elsevier, 2014-11-07)Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor required for survival of neurons in the central and peripheral nervous system. Specifically, GDNF has been characterized as a survival factor for ... -
Ensemble-based screening of natural products and FDA-approved drugs identified potent inhibitors of SARS-CoV-2 that work with two distinct mechanisms
(Elsevier Ltd., 2021-06)The recent outbreak of SARS-CoV-2 is responsible for high morbidity and mortality rate across the globe. This requires an urgent identification of drugs and other interventions to overcome this pandemic. Computational ... -
Ensemble-based screening of natural products and FDA-approved drugs identified potent inhibitors of SARS-CoV-2 that work with two distinct mechanisms
(Elsevier Inc., 2021-02-23)The recent outbreak of SARS-CoV-2 is responsible for high morbidity and mortality rate across the globe. This requires an urgent identification of drugs and other interventions to overcome this pandemic. Computational drug ... -
Exercise-dependent regulation of glial cell line-derived neurotrophic factor (GDNF) expression in skeletal muscle and its importance for the neuromuscular system
(Higher Education Press and Springer-Verlag Berlin Heidelberg, 2012)The focus of this review is to highlight the importance of glial cell line-derived neurotrophic factor (GDNF) for the motor nervous system. GDNF is the most potent survival factor for motor neurons, where it enhances maintenance ... -
The extended scope of neuroimaging and prospects in brain atrophy mitigation: a systematic review
(Elsevier B.V., 2020-08-15)Brain atrophy is a condition associated with a reduction of brain volume. It is a common manifestation of aging even though it occurs in some childhood conditions and carried forward to pre-senile middle age. There are ... -
Factors Contributing to Retention in Care and Treatment Adherence Among People Living With HIV Returning to Care in South-Eastern Tanzania: A Qualitative Study
(Taylor & Francis online, 2025-02-04)Background People living with HIV (PLHIV) with good adherence to antiretroviral therapy (ART) achieve good health outcomes. However, treatment interruptions remain a major challenge, particularly in rural Africa. This ... -
Germination of Invasive Plant Seeds after Digestion by Horses in California
(Natural Areas Journal, 2008-10)Using a unique sterile design intended to eliminate outside seed contamination of horse feces, we investigated whether weed seeds germinate after digestion by horses. Feces were collected from selected National Parks and ... -
Graphene and graphene like 2D graphitic carbon nitride: Electrochemical detection of food colorants and toxic substances in environment
(Elsevier, 2019)Excessive consumption of substances such as food colorants, exposure to doses of metal ions, antibiotic residues and pesticides residues above maximum tolerance limit have a detrimental effect on human health. Hence in ... -
Implementation of One Health Approach in Tanzania: Strengths and Challenges
(CABI Digital Library, 2024-06-26)One Health (OH) approach has recently been defined by the OH High-Level Expert Panel (OHHLEP) as an integrated, unifying approach that aims to sustainably balance and optimize the health of people, animals, and ecosystems. ... -
In vivo evaluation of Spirulina platensis for nutrient bioavailability in mice
(Indian Journal, 2021)Spirulina, a photosynthetic blue-green alga (cyanobacterium), has drawn attention as a viable food supplement due to its suitable nutrient content. Despite its suitable nutrient composition, the bioavailability of nutrients ... -
Luteolin: a blocker of SARS-CoV-2 cell entry based on relaxed complex scheme, molecular dynamics simulation, and metadynamics
(Springer Nature, 2021-07-08)Natural products have served human life as medications for centuries. During the outbreak of COVID-19, a number of naturally derived compounds and extracts have been tested or used as potential remedies against COVID-19. ... -
Measuring Serum Toxicity Markers to Evaluate the Safety of Commercially Available Spirulina Products in Mice
(Current Research in Nutrition and Food Science, 2021-03-20)Spirulina a multicellular, blue-green alga has drawn attention as a viable food supplement due to its suitable nutrient composition, however, there is a dearth of information regarding its safety. This study aimed to measure ... -
The neurochemistry and social flow of singing: bonding and oxytocin.
(Frontiers in Human Neuroscience, 2015-09-23)Music is used in healthcare to promote physical and psychological well-being. As clinical applications of music continue to expand, there is a growing need to understand the biological mechanisms by which music influences ... -
The neuroimaging magnitude of pediatric brain atrophy in northern Tanzania
(The Pan African Medical Journal, 2020-05-21)Introduction: the loss of parenchymal brain volume per normative age comparison is a distinctive feature of brain atrophy. While the condition is the most prevalent to elderly, it has also been observed in pediatric ages. ... -
Prevalence and risk factors of brain atrophy and associated confusion state among adults from three hospitals in northern Tanzania
(African Field Epidemiology Network, 2023-05-02)Introduction: brain atrophy is the reduction of brain volume often accompanied with cognitive changes.Despite the availability of computerized- tomography (CT) scanners in Tanzania, little is known about the magnitude of ... -
Prevalence and Risk Factors of Human Taenia solium Cysticercosis in Mbulu District, Northern Tanzania
(MDPI, 2024-05-23)Background: Taeniosis and cysticercosis are human infections caused by the pork tapeworm, Taenia solium. This study is a baseline for community-based intervention. We determined the prevalence of human cysticercosis and ...
