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Standardization of natural mycolic acid antigen composition and production for use in biomarker antibody detection to diagnose active tuberculosis

Ndlandla, F.L.; Ejoh, V.; Stoltz, A.C.; Naicker, B.; Cromarty, A.D.; van Wyngaardt, S.; Khati, M.; Rotherham, L.S.; Lemmer, Y.; Niebuhr, J.; Baumeister, C.R.; Al Dulayymi, J.R.; Swai, Hulda; Baird, M.S.; Verschoor, J.A. (Elsevier B.V., 2016-08)

Mycobacterium tuberculosis, the causative agent of tuberculosis, is characterized by the abundance of species specific, antigenic cell wall lipids called mycolic acids. These wax-like molecules all share an identical, ...

Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis

Lemmer, Yolandy; Kalombo, Lonji; Pietersen, Ray-Dean; Jones, Arwyn T.; Semete-Makokotlela, Boitumelo; Van Wyngaardt, Sandra; Ramalapa, Bathabile; Stoltz, Anton C.; Baker, Bienyameen; Verschoor, Jan A.; Swai, Hulda; de Chastellier, Chantal (Elsevier, 2015-06-06)

The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologiesmight ...

Prevalence of Hypertension and Its Association with Tuberculosis, among HIV patients on ART in Bagamoyo District, Eastern Tanzania

Nyangi, Getera Isack; Festo, Charles; Olotu, Ally (International Journal of AIDS, 2019-11-27)

Background: Individuals living with HIV/AIDS have a higher risk of cardiovascular complications, including hypertension. We, therefore, assess the prevalence of hypertension and its association with Tuberculosis in HIV ...

Impact of N-Acetyl Cysteine (NAC) on Tuberculosis (TB) Patients—A Systematic Review

Mapamba, Daniel; Sauli, Elingarami; Mrema, Lucy; Lalashowi, Julieth; Magombola, David; Buza, Joram; Olomi, Willyhelmina; Wallis, Robert; Ntinginya, Nyanda (MDPI, 2022-11-21)

Sustained TB infection overproduces reactive oxygen species (ROS) as a host defense mechanism. Research shows ROS is destructive to lung tissue. Glutathione (GSH) neutralizes ROS, although it is consumed. NAC is a precursor ...

Multiple Pathogens Contribute to Human Immunodeficiency Virus-Related Sepsis in Addition to Mycobacterium tuberculosis: A Prospective Cohort in Tanzania

Tsere, Donatus; Shirima, Gabriel; Grundy, Brian; Heysell, Scott; Mpagama, Stellah; Mziray, Shabani; Mbelele, Peter (PubMed Central, 2022-10-20)

Background: Mortality from tuberculosis (TB) sepsis is common among patients living with human immunodeficiency virus (PLHIV). We aimed to detect M. tuberculosis (MTB) and additional sepsis etiologies, and mortality ...

Mycobacterium bovis in rural Tanzania: Risk factors for infection in human and cattle populations

Cleaveland, Sarah; Shawa, Darren; Mfinanga, Sayoki; Shirima, Gabriel; Kazwala, Rudovick; Eblatee, Ernest; Sharp, Michael (Elsevier Ltd., 2007-01)

Although bovine tuberculosis is widespread throughout Africa, very little is known about risk factors for Mycobacterium bovis infection in either human or cattle populations. A human case–control study was conducted in ...