Browsing Research Articles [LISBE] by Author "Dube, Admire"
Now showing items 1-5 of 5
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Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes
Omarch, Geofrey; Kippie, Yunus; Mentor, Shireen; Ebrahim, Naushaad; Fisher, David; Murilla, Grace; Swai, Hulda; Dube, Admire (Taylor & Francis Group., 2019-04-22)Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based ... -
Curdlan-Conjugated PLGA Nanoparticles Possess Macrophage Stimulant Activity and Drug Delivery Capabilities
Tukulula, Matshawandile; Hayeshi, Rose; Fonteh, Pascaline; Meyer, Debra; Ndamase, Abongile; Madziva, Michael T.; Khumalo, Vincent; Lubuschagne, Philip; Naicker, Brendon; Swai, Hulda; Dube, Admire (Springer, 2015-03-28)Purpose There is significant interest in the application of nanoparticles to deliver immunostimulatory signals to cells.We hypothesized that curdlan (immune stimulating polymer) could be conjugated to PLGA and nanoparticles ... -
Nanomedicine: Past, present and future - A global perspective.
Chang, Esther; Harford, Joe; Eaton, Michael; Boisseau, Patrick; Dube, Admire; Hayeshi, Rose; Swai, Hulda; Lee, Dong (Elsevier Inc, 2015-12-18)Nanomedicine is an emerging and rapidly evolving field and includes the use of nanoparticles for diagnosis and therapy of a variety of diseases, as well as in regenerative medicine. In this mini-review, leaders in the field ... -
Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice
Melariri, Paula; Kalombo, Lonji; Nkuna, Patric; Dube, Admire; Hayeshi, Rose; Ogutu, Benhards; Gibhard, Liezl; deKock, Carmen; Smith, Peter; Wiesner, Lubbe; Swai, Hulda (Dovepress, 2015-02-20): Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. A microemulsion formulation of TQ ... -
State of the art and future directions in nanomedicine for tuberculosis.
Dube, Admire; Lemmer, Yolandy; Hayeshi, Rose; Balogun, Mohammed; Labuschagne, Philip; Swai, Hulda; Kalombo, Lonji (Expert Opinion on Drug Delivery, 2013-12-01)Introduction: Tuberculosis (TB) ranks the second leading cause of death from an infectious disease worldwide. However, treatment of TB is affected by poor patient compliance due to the requirement for daily drug administration, ...