Browsing Life sciences and Bio-engineering by Author "Kazwala, Rudovick"
Now showing items 1-15 of 15
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Combining Multiple Assays Improves Detection and Serotyping of Foot-and-Mouth Disease Virus. A Practical Example with Field Samples from East Africa
(MDPI, 2021-08-10)Multiple serotypes and topotypes of foot-and-mouth disease virus (FMDV) circulate in endemic areas, posing considerable impacts locally. In addition, introductions into new areas are of great concern. Indeed, in recent ... -
Complete genome sequence of Brucella abortus isolated from a human blood culture sample in Tanzania
(American society for microbiology, 2024-01-30)Brucella abortus causes infections in humans and livestock. Bacterial isolates are challenging to obtain, and very little is known about the genomic epidemiology of this species in Africa. Here, we report the complete ... -
Integrating contact tracing and whole- genome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study
(eLife Sciences Publications Ltd, 2023-05-25)Background: Dog-mediated rabies is endemic across Africa causing thousands of human deaths annually. A One Health approach to rabies is advocated, comprising emergency post-exposure vaccination of bite victims and mass ... -
Integrating contact tracing and wholegenome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study
(eLife, 2023-05-23)Background: Dog-mediated rabies is endemic across Africa causing thousands of human deaths annually. A One Health approach to rabies is advocated, comprising emergency post-exposure vaccination of bite victims and mass ... -
Integrating serological and genetic data to quantify cross-species transmission: brucellosis as a case study
(Cambridge University Press, 2016-03-03)Epidemiological data are often fragmented, partial, and/or ambiguous and unable to yield the desired level of understanding of infectious disease dynamics to adequately inform control measures. Here, we show how the ... -
Latent class evaluation of the performance of serological tests for exposure to Brucella spp. in cattle, sheep, and goats in Tanzania
(PLOS Medicine, 2021-08-24)Brucellosis is a neglected zoonosis endemic in many countries, including regions of sub-Saharan Africa. Evaluated diagnostic tools for the detection of exposure to Brucella spp. are important for disease surveillance and ... -
Molecular epidemiology of Brucella species in mixed livestock-human ecosystems in Kenya
(Springer Nature Limited, 2021-04-23)Brucellosis, caused by several species of the genus Brucella, is a zoonotic disease that affects humans and animal species worldwide. Information on the Brucella species circulating in different hosts in Kenya is largely ... -
Mycobacterium bovis in rural Tanzania: Risk factors for infection in human and cattle populations
(Elsevier Ltd., 2007-01)Although bovine tuberculosis is widespread throughout Africa, very little is known about risk factors for Mycobacterium bovis infection in either human or cattle populations. A human case–control study was conducted in ... -
One Health contributions towards more effective and equitable approaches to health in low- and middle-income countries
(Published by the Royal Society, 2017)Emerging zoonoses with pandemic potential are a stated priority for the global health security agenda, but endemic zoonoses also have a major societal impact in low-resource settings. Although many endemic zoonoses can ... -
One Health: a concept led by Africa, with global benefits
(BMJ Publishing Group, 2015-05-09)One Health evolved from the recognition that an interdisciplinary approach is required to understand complex health problems, and that the health of humans and animals are inextricably linked. Through closer ... -
Performance characteristics and costs of serological tests for brucellosis in a pastoralist community of northern Tanzania
(Springer Nature Limited, 2021-03-09)The control of brucellosis across sub-Saharan Africa is hampered by the lack of standardized testing and the use of tests with poor performance. This study evaluated the performance and costs of serological assays for human ... -
Prevalence and risk factors for human leptospirosis at a hospital serving a pastoralist community, Endulen, Tanzania
(PLOS Neglected Tropical Diseases, 2023-12-20)Background Leptospirosis is suspected to be a major cause of illness in rural Tanzania associated with close contact with livestock. We sought to determine leptospirosis prevalence, identify infecting Leptospira serogroups, ... -
Prevalence and risk factors for Q fever, spotted fever group rickettsioses, and typhus group rickettsioses in a pastoralist community of northern Tanzania, 2016–2017
(John Wiley & Sons Ltd., 2024-01-12)Background: In northern Tanzania, Q fever, spotted fever group (SFG) rickettsioses, and typhus group (TG) rickettsioses are common causes of febrile illness. We sought to describe the prevalence and risk factors for these ... -
Prevalence and speciation of brucellosis in febrile patients from a pastoralist community of Tanzania.
(Springer Nature Limited, 2020-04-27)Brucellosis is an endemic zoonosis in sub-Saharan Africa. Pastoralists are at high risk of infection but data on brucellosis from these communities are scarce. The study objectives were to: estimate the prevalence of human ... -
Serological and molecular evidence of Brucella species in the rapidly growing pig sector in Kenya.
(BioMed Central Ltd, 2020-05-11)Background: Brucellosis is an emerging yet neglected zoonosis that has been reported in Kenya. Epidemiological data on brucellosis in ruminants is readily accessible; however, reports on brucellosis in pigs remain limited. ...
