Browsing Life sciences and Bio-engineering by Author "Cleaveland, Sarah"
Now showing items 1-20 of 33
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African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa
(MDPI, 2021-11-15)African swine fever (ASF) is a highly infectious and fatal haemorrhagic disease of pigs that is caused by a complex DNA virus of the genus Asfivirus and Asfarviridae African suids family. The disease is among the most ... -
Classification and characterisation of livestock production systems in northern Tanzania.
(PLOS ONE, 2020-12-30)Livestock keepers in sub-Saharan Africa face a range of pressures, including climate change, land loss, restrictive policies, and population increase. Widespread adaptation in response can lead to the emergence of new, ... -
Detection of African swine fever virus genotype XV in a sylvatic cycle in Saadani National Park, Tanzania
(Wiley Online Library, 2020-07-22)African swine fever (ASF) is a severe haemorrhagic disease of domestic pigs caused by ASF virus (ASFV). ASFV is transmitted by soft ticks (Ornithodoros moubata complex group) and by direct transmission. In Africa, ASF ... -
Development, feasibility and potential effectiveness of community-based continuous mass dog vaccination delivery strategies: lessons for optimization and replication
(bioRxiv, 2022-03-13)Objectives Dog vaccination can eliminate rabies, but annual delivery strategies do not sustain vaccination coverage between campaigns. We describe the development of a community-based continuous mass dog vaccination (CBC-MDV) ... -
Economic Burden of Livestock Abortions in Northern Tanzania
(Cambridge University press, 2024)Livestock abortion is a source of economic loss for farmers, but its economic impact has not been estimated in many Low and Middle-Income Countries. This article presents an estimation methodology and estimates for the ... -
The first genotype II African swine fever virus isolated in Africa provides insight into the current Eurasian pandemic
(Scientific Reports, 2021-06-22)African swine fever (ASF) caused by the African swine fever virus (ASFV) is ranked by OIE as the most important source of mortality in domestic pigs globally and is indigenous to African wild suids and soft ticks. Despite ... -
“He Who Relies on His Brother's Property Dies Poor”: The Complex Narratives of Livestock Care in Northern Tanzania
(Frontiers in Veterinary Science, 2021-11-03)Background: Endemic zoonoses have important impacts for livestock-dependent households in East Africa. In these communities, people's health and livelihoods are severely affected by livestock disease losses. Understanding ... -
How can we realise the full potential of animal health systems for delivering development and health outcomes?
(Europe PMC, 2021-08-21)Animal health services play an essential role in supporting livestock production, with the potential to address the challenges of hunger, poverty, health, social justice and environmental health as part of the path towards ... -
Identifying Age Cohorts Responsible for Peste Des Petits Ruminants Virus Transmission among Sheep, Goats, and Cattle in Northern Tanzania.
(MDPI, 2020-02-07)Peste des petits ruminants virus (PPRV) causes a contagious disease of high morbidity and mortality in global sheep and goat populations. To better control this disease and inform eradication strategies, an improved ... -
Integrating a community-based continuous mass dog vaccination delivery strategy into the veterinary system of Tanzania: A process evaluation using normalization process theory
(Elsevier, 2023-06-03)Abstract: Sustained vaccination coverage of domestic dog populations can interrupt rabies transmission. How- ever, challenges remain including low dog owner participation, high operational costs associated with ... -
Integrating contact tracing and whole- genome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study
(eLife Sciences Publications Ltd, 2023-05-25)Background: Dog-mediated rabies is endemic across Africa causing thousands of human deaths annually. A One Health approach to rabies is advocated, comprising emergency post-exposure vaccination of bite victims and mass ... -
Integrating contact tracing and wholegenome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study
(eLife, 2023-05-23)Background: Dog-mediated rabies is endemic across Africa causing thousands of human deaths annually. A One Health approach to rabies is advocated, comprising emergency post-exposure vaccination of bite victims and mass ... -
Integrating serological and genetic data to quantify cross-species transmission: brucellosis as a case study
(Cambridge University Press, 2016-03-03)Epidemiological data are often fragmented, partial, and/or ambiguous and unable to yield the desired level of understanding of infectious disease dynamics to adequately inform control measures. Here, we show how the ... -
Inter-epidemic Rift Valley fever virus infection incidence and risks for zoonotic spillover in northern Tanzania
(PLOS, 2022-10-28)Rift Valley fever virus (RVFV) is a mosquito-borne pathogen that has caused epidemics involving people and animals across Africa and the Arabian Peninsula. A number of studies have found evidence for the circulation of ... -
Latent class evaluation of the performance of serological tests for exposure to Brucella spp. in cattle, sheep, and goats in Tanzania
(PLOS Medicine, 2021-08-24)Brucellosis is a neglected zoonosis endemic in many countries, including regions of sub-Saharan Africa. Evaluated diagnostic tools for the detection of exposure to Brucella spp. are important for disease surveillance and ... -
Low topotype diversity of recent foot-and-mouth disease virus serotypes O and A from districts located along the Uganda and Tanzania border.
(The Korean Society of Veterinary Science, 2019-03-01)Foot-and-mouth disease (FMD) is one of the most important livestock diseases in East Africa with outbreaks reported annually that cause severe economic losses. It is possible to control disease using vaccination, but ... -
Mycobacterium bovis in rural Tanzania: Risk factors for infection in human and cattle populations
(Elsevier Ltd., 2007-01)Although bovine tuberculosis is widespread throughout Africa, very little is known about risk factors for Mycobacterium bovis infection in either human or cattle populations. A human case–control study was conducted in ... -
Occurrence of Foot-and-Mouth Disease Virus Serotypes in Uganda and Tanzania (2003 to 2015): A Review and Implications for Prospective Regional Disease Control
(Journal of Agricultural Science, 2020-05-15)Endemic foot-and-mouth disease (FMD) presents a global economic challenge to the livestock industry. The progressive control pathway for FMD (PCP-FMD) specifies successive steps through which a country/region can reduce ... -
One Health contributions towards more effective and equitable approaches to health in low- and middle-income countries
(Published by the Royal Society, 2017)Emerging zoonoses with pandemic potential are a stated priority for the global health security agenda, but endemic zoonoses also have a major societal impact in low-resource settings. Although many endemic zoonoses can ... -
Participation in mass dog vaccination campaigns in Tanzania: Benefits of community engagement
(Frontiers, 2022-10-13)Background: Canine rabies causes about 59,000 human deaths each year globally but the disease can be eliminated by sustaining sufficient dog vaccination coverage over several consecutive years. A challenge to achieving ...
