| dc.description.abstract | Aim: The purpose of this study was to investigate the effect of dietary sesame oil and ginger
oil supplements on the dorsal root ganglia following a sciatic nerve crush model in male Wistar
albino rats.
Materials and methods: Crush injury models have been done by means of graded forceps (50
Newton). The animals were given a daily sesame oil (4ml/kg/day) and ginger oil (400mg/kg/
day) via oral gavage for a period of 28days. Dorsal root ganglia from the L5 levels were harvested.
Processing of tissues was done for electron microscopy and light microscopy. Immunohistochemical
staining with active caspase-3 antibody and qualitative ultrastructural analyses of tissues were
made by a light and a transmission electron microscope, respectively.
Results: The results showed that crush injury leads to remarkable ultrastructural changes in
sensory neurons, such as swollen mitochondria, disruption of cristae structure, glial cell
proliferation and, consequently, phagocytosis of the damaged neuron. These ultrastructural
changes were less evident in the treated groups, and both natural compounds reduced the
expression of activated caspase-3, which may also affect ultrastructural changes.
Conclusion: The application of the natural products sesame oil and ginger oil may represent a
supportive approach to the protection of sensory neurons against the destructive effects of
peripheral nerve crush injury | en_US |
