xmlui.dri2xhtml.structural.head-subtitle

Exercise-dependent regulation of glial cell line-derived neurotrophic factor (GDNF) expression in skeletal muscle and its importance for the neuromuscular system

Show simple item record

dc.contributor.author Vianney, John-Mary
dc.contributor.author McCullough, Monica J.
dc.contributor.author Gyorkos, Amy M.
dc.contributor.author Spitsbergen, John M.
dc.date.accessioned 2020-02-12T06:45:51Z
dc.date.available 2020-02-12T06:45:51Z
dc.date.issued 2012
dc.identifier.uri DOI 10.1007/s11515-012-1201-7
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/550
dc.description This research articles published by Higher Education Press and Springer-Verlag Berlin Heidelberg, 2012 en_US
dc.description.abstract The focus of this review is to highlight the importance of glial cell line-derived neurotrophic factor (GDNF) for the motor nervous system. GDNF is the most potent survival factor for motor neurons, where it enhances maintenance and survival of both developing and mature motor neurons in vivo and in vitro. GDNF aids in neuromuscular junction formation, maintenance, and plasticity, where skeletal muscle-derived GDNF may be responsible for this phenomenon. Increased levels of physical activity can increase GDNF protein levels in skeletal muscle, where alterations in acetylcholine and acetylcholine receptor activation may be involved in regulation of these changes observed. With inactivity and disuse, GDNF expression shows different patterns of regulation in the central and peripheral nervous systems. Due to its potent effects for motor neurons, GDNF is being extensively studied in neuromuscular diseases. en_US
dc.language.iso en en_US
dc.publisher Higher Education Press and Springer-Verlag Berlin Heidelberg en_US
dc.subject glial cell line-derived neurotrophic factor en_US
dc.subject neuromuscular junction en_US
dc.subject motor neurons en_US
dc.subject skeletal muscle en_US
dc.title Exercise-dependent regulation of glial cell line-derived neurotrophic factor (GDNF) expression in skeletal muscle and its importance for the neuromuscular system en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search Our NM-AIST IR


Browse NM-AIST IR

My NM-AIST IR Account

Statistics