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Characterization of Polycaprolactone and Rice Husk Silica Composite (PCL-SiO2) by E-Spinning to Apply Supporter for Drug Release

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dc.contributor.author Song, Sinae
dc.contributor.author Hilonga, Askwar
dc.contributor.author Kim, Hee Taik
dc.date.accessioned 2019-11-13T09:43:10Z
dc.date.available 2019-11-13T09:43:10Z
dc.date.issued 2017
dc.identifier.uri doi :10.1088/1742-6596/987/1/012013
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/517
dc.description Research Article published by IOP Publishing en_US
dc.description.abstract Abstract. Polycaprolactone (PCL) is an interesting material to apply biomedical field owing to its biodegradability and biocompatibility which is suitable for a specific site with longer healing times. Blending the polymer with other materials has degradation property improved with the effective and economic method. This study was conducted to fabricate supporter based on Polycaprolactone and Rice husk silica (PCL-SiO2) by using electrospinning. Nano-porous silica in the composite was synthesized from rice husk having properties of economic, ecofriendly and high surface area. It drew to enhance the amount of drug loading in the carrier. Electrospinning technique is used to fabricate fibrous component by optimization condition obtained from previous mechanical properties experiments. Release experiment was carried out by the degree of dye absorbance at 544nm by ultraviolet–visible spectroscopy, the RhB in SiO2 alternative drug for modelling of drug release was released for 1 ~ 20 days at 37°C in phosphate buffer. Furthermore, the Mechanical property was confirmed by DSC, TGA. Morphology and degree of biodegradation were shown as SEM images and EDS. en_US
dc.language.iso en en_US
dc.publisher IOP Publishing Ltd en_US
dc.subject Research Subject Categories::NATURAL SCIENCES en_US
dc.title Characterization of Polycaprolactone and Rice Husk Silica Composite (PCL-SiO2) by E-Spinning to Apply Supporter for Drug Release en_US
dc.type Article en_US


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