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Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at OnceWeekly Administration for the Duration of Treatment

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dc.contributor.author Kalombo, Lonji
dc.contributor.author Lemmer, Yolandy
dc.contributor.author Semete-Makokotlela, Boitumelo
dc.contributor.author Ramalapa, Bathabile
dc.contributor.author Nkuna, Patric
dc.contributor.author Booysen, Laetitia L.L.I.J.
dc.contributor.author Naidoo, Saloshnee
dc.contributor.author Hayeshi, Rose
dc.contributor.author Verschoor, Jan A.
dc.contributor.author Swai, Hulda
dc.date.accessioned 2019-10-18T10:50:58Z
dc.date.available 2019-10-18T10:50:58Z
dc.date.issued 2019-08-15
dc.identifier.uri doi:10.3390/nano9081167
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/509
dc.description Research Article published by MDPI en_US
dc.description.abstract Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of existing drugs would allow decreasing the treatment frequency to weekly, thereby ultimately improving patient compliance. Nanoencapsulation of three first-line anti-TB drugs was achieved by a unique, scalable spray-drying technology forming free-flowing powders in the nanometer range with encapsulation e ciencies of 82, 75, and 62% respectively for rifampicin, pyrazinamide, and isoniazid. In a pre-clinical study on TB infected mice, we demonstrate that the encapsulated drugs, administered once weekly for nine weeks, showed comparable e cacy to daily treatment with free drugs over the same experimental period. Both treatment approaches had equivalent outcomes for resolution of inflammation associated with the infection of lungs and spleens. These results demonstrate how scalable technology could be used to manufacture nanoencapsulated drugs. The formulations may be used to reduce the oral dose frequency from daily to once weekly in order to treat uncomplicated TB. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.subject nanomedicine en_US
dc.subject spray-drying technology en_US
dc.subject dose frequency en_US
dc.title Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at OnceWeekly Administration for the Duration of Treatment en_US
dc.type Article en_US


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