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Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

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dc.contributor.author Shadrack, Daniel M.
dc.contributor.author Swai, Hulda S.
dc.contributor.author Munissi, Joan J. E.
dc.contributor.author Mubofu, Egid B.
dc.contributor.author Nyandoro, Stephen S.
dc.date.accessioned 2019-10-18T10:22:52Z
dc.date.available 2019-10-18T10:22:52Z
dc.date.issued 2018-06-12
dc.identifier.uri doi:10.3390/molecules23061419
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/508
dc.description Research Article published MDPI en_US
dc.description.abstract Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties. Experimental and computational studies have reported on the therapeutic potential of polyamidoamine (PAMAM) dendrimers as solubility enhancers in pre-clinical and clinical settings. Besides formulation strategies, factors such as pH, PAMAM dendrimer generation, PAMAM dendrimer concentration, nature of the PAMAM core, special ligand and surface modifications of PAMAM dendrimer have an influence on drug solubility and other recommendable pharmacological properties. This review, therefore, compiles the recently reported applications of PAMAM dendrimers in pre-clinical and clinical uses as enhancers of solubility and other desirable properties such as sustained and controlled release, bioavailability, bio-distribution, toxicity reduction or enhancement, and targeted delivery of small molecules with emphasis on cancer treatment. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.subject PAMAM dendrimer en_US
dc.subject solubility enhancement en_US
dc.subject drug delivery en_US
dc.subject small molecules en_US
dc.title Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies en_US
dc.type Article en_US


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