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Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles.

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dc.contributor.author Omwoyo, Wesley N
dc.contributor.author Melariri, Paula
dc.contributor.author Gathirwa, Jeremiah W
dc.contributor.author Oloo, Florence
dc.contributor.author Mahanga, Geoffrey M
dc.contributor.author Kalombo, Lonji
dc.contributor.author Ogutu, Bernhards
dc.contributor.author Swai, Hulda
dc.date.accessioned 2019-10-16T09:00:19Z
dc.date.available 2019-10-16T09:00:19Z
dc.date.issued 2016-04-01
dc.identifier.other 26724538
dc.identifier.uri https://doi.org/10.1016/j.nano.2015.11.017
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/492
dc.description Research Article published by Elsevier Volume 12, Issue 3, April 2016 en_US
dc.description.abstract Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA into solid lipid nanoparticles (SLNs) as a nanomedicine drug delivery system. DHA-SLNs were characterized for physical parameters and evaluated for in vitro and in vivo antimalarial efficacy. DHA-SLNs showed desirable particle characteristics including particle size (240.7 nm), particle surface charge (+ 17.0 mV), drug loadings (13.9 wt %), encapsulation efficacy (62.3%), polydispersity index (0.16) and a spherical appearance. Storage stability up to 90 days and sustained release of drug over 20 h was achieved. Enhanced in vitro (IC50 0.25 ng/ml) and in vivo (97.24% chemosuppression at 2 mg/kg/day) antimalarial activity was observed. Enhancement in efficacy was 24% when compared to free DHA. These encouraging results show potential of using the described formulation for DHA drug delivery for clinical application. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Dihydroartemisinin en_US
dc.subject Nanomedicine drug delivery en_US
dc.subject Solid lipid nanoparticles en_US
dc.title Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles. en_US
dc.type Article en_US


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