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Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method.

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dc.contributor.author Tshweu, Lesego
dc.contributor.author Katata, Lebogang
dc.contributor.author Kalombo, Lonji
dc.contributor.author Chiappetta, Diego A
dc.contributor.author Hocht, Christian
dc.contributor.author Sosnik, Alejandro
dc.contributor.author Swai, Hulda
dc.date.accessioned 2019-10-16T08:24:47Z
dc.date.available 2019-10-16T08:24:47Z
dc.date.issued 2014-10-17
dc.identifier.issn 1748-6963
dc.identifier.other 24364871
dc.identifier.uri https://doi.org/10.2217/nnm.13.167
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/491
dc.description Research Article published by NANOMEDICINEVOL. 9, NO. 12 en_US
dc.description.abstract Aim: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. Materials & methods: EFV-loaded PCL NPs were produced by a double-emulsion/spray-drying method. Results: NPs displayed a hydrodynamic diameter of 200–250 nm. The encapsulation efficiency was 86–93% and the mass recovery was above 60%. X-ray diffraction indicated that drug and PCL underwent amorphization during the spray-drying process. Encapsulation within NPs significantly increased the maximum concentration in plasma and the bioavailability. Conclusion: EFV-loaded PCL NPs represent a promising platform to develop scalable pharmaceuticals with improved (bio)pharmaceutic performance. en_US
dc.language.iso en en_US
dc.publisher NANOMEDICINE en_US
dc.subject HIV en_US
dc.subject Efavirenz en_US
dc.subject In vitro drug release en_US
dc.subject Oral bioavailability enhancement en_US
dc.subject Poly(epsilon-caprolactone) nanoparticle en_US
dc.subject Spray drying en_US
dc.title Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method. en_US
dc.type Article en_US


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