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Preparation of rifampicin/poly(d,l-lactice) nanoparticles for sustained release by supercritical assisted atomization technique

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dc.contributor.author Labuschagne, P. W.
dc.contributor.author Adami, R.
dc.contributor.author Liparoti, S.
dc.contributor.author Naidoo, S.
dc.contributor.author Reverchon, E.
dc.contributor.author Swai, H.
dc.date.accessioned 2019-10-16T06:35:05Z
dc.date.available 2019-10-16T06:35:05Z
dc.date.issued 2014-11
dc.identifier.uri https://doi.org/10.1016/j.supflu.2014.08.004
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/487
dc.description Research Article published by Elsevier Volume 95 en_US
dc.description.abstract In this work supercritical assisted atomization (SAA) process was used for the co-precipitation of poly(d,l-lactide) (PDLLA) and rifampicin (RIF) as nanoparticles for sustained release applications. The effect of the variation of PDLLA/RIF ratio on co-precipitate characteristics was mainly investigated. The precipitated particles were analyzed in terms of their morphological, thermodynamic and crystallographic properties. In addition, loading efficiency and in-vitro release studies were conducted. Spherical PDLLA/RIF nanoparticles with mean diameter ranging from 123 to 148 nm were prepared. Loading efficiency was greater than 100% resulting in RIF loadings of 28.8 to 50.5%. X-ray diffraction revealed that the encapsulated RIF is in an amorphous state, while NMR spectra indicated no structural modifications after the SAA process. In-vitro release studies showed an initial burst release of 80–87% of total RIF loaded, necessary to suppress the generation of resistance by the microorganism, followed by first-order sustained release between 0.4 and 0.8 mg/L RIF per day over a period of 17 days. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Supercritical assisted atomization (SAA) en_US
dc.subject Nano-encapsulation en_US
dc.title Preparation of rifampicin/poly(d,l-lactice) nanoparticles for sustained release by supercritical assisted atomization technique en_US
dc.type Article en_US


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