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In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid.

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dc.contributor.author Booysen, L L I J
dc.contributor.author Kalombo, L
dc.contributor.author Brooks, E
dc.contributor.author Hansen, R
dc.contributor.author Gilliland, J
dc.contributor.author Gruppo, V
dc.contributor.author Lungenhofer, P
dc.contributor.author Semete-Makokotlela, B
dc.contributor.author Swai, H S
dc.contributor.author Kotze, A F
dc.contributor.author Lenaerts, A
dc.contributor.author du Plessis, L H
dc.date.accessioned 2019-10-11T08:16:04Z
dc.date.available 2019-10-11T08:16:04Z
dc.date.issued 2013-02-28
dc.identifier.other 23357255
dc.identifier.uri https://doi.org/10.1016/j.ijpharm.2013.01.038
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/486
dc.description Research Article published by Elsevier B.V. en_US
dc.description.abstract Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229±7.6 to 382±23.9nm), uniform size distribution and positive zeta potential (+12.45±4.53mV). In vitro/in vivo assays were performed to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) performance of these nanoparticles following nanoencapsulation of the anti-tuberculosis drugs rifampicin (RIF) and isoniazid (INH). The results demonstrated the potential for the reduction in protein binding of these drugs by protection in the polymer core. Furthermore, in vitro efficacy was demonstrated using Mycobacterium tuberculosis (M. tb.) (strain H37Rv). Sustained drug release over seven days were observed for these drugs following once-off oral administration in mice with subsequent drug distribution of up to 10 days in the liver and lungs for RIF and INH, respectively. It was concluded by these studies combined with our previous reports that spray-dried PLGA nanoparticles demonstrate potential for the improvement of tuberculosis chemotherapy by nanoencapsulation of anti-tuberculosis drugs. en_US
dc.language.iso en en_US
dc.publisher Elsevier B.V. en_US
dc.subject Pharmacokinetic en_US
dc.subject Pharmacodynamic en_US
dc.title In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid. en_US
dc.type Article en_US


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