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Trypanosome non-specific IgM antibodies detected in serum of Trypanosoma congolense-infected cattle are polyreactive

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dc.contributor.author Buza, Joram
dc.contributor.author Naessens, Jan
dc.date.accessioned 2019-10-10T08:51:59Z
dc.date.available 2019-10-10T08:51:59Z
dc.date.issued 1999-07-01
dc.identifier.uri https://doi.org/10.1016/S0165-2427(99)00033-1
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/481
dc.description Research Article published by Elsevier Science Volume 69, Issue 1, 1 July 1999 en_US
dc.description.abstract Serum Ig from Trypanosoma congolense-infected cattle were affinity-purified using immobilised trypanosome or non-trypanosome antigens (ß-galactosidase, cytochrome C and ferritin). The bound and unbound IgG and IgM fractions were collected and tested in ELISA for reactivity to each antigen. The results indicated that the presence of reactivity to non-parasite antigens in serum of infected cattle is due to polyreactive IgM antibodies. However, the IgG fraction only bound to trypanosome antigens and was only present in post-infection sera, indicating that it was induced by the infecting trypanosomes. Since the polyreactive IgM antibodies were also present in pre-infection sera, it is probable that they were natural antibodies that were not induced but only amplified by the trypanosome infection. en_US
dc.language.iso en en_US
dc.publisher Elsevier Science en_US
dc.subject Trypanosoma conglense en_US
dc.subject Polyreactive antibodies en_US
dc.subject Natural antibodies en_US
dc.title Trypanosome non-specific IgM antibodies detected in serum of Trypanosoma congolense-infected cattle are polyreactive en_US
dc.type Article en_US


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