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Modeling the proteome of a Marek's disease transformed cell line: a natural animal model for CD30 overexpressing lymphomas.

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dc.contributor.author Buza, Joram J
dc.contributor.author Burgess, Shane C
dc.date.accessioned 2019-10-10T07:58:34Z
dc.date.available 2019-10-10T07:58:34Z
dc.date.issued 2007-04-18
dc.identifier.other 17443643
dc.identifier.uri https://doi.org/10.1002/pmic.200600946
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/479
dc.description Research Article published by Volume7, Issue8, 18 April 2007 en_US
dc.description.abstract Marek's disease (MD) in the chicken, caused by the highly infectious MD alpha-herpesvirus (MDV), is both commercially important and a unique, naturally occurring model for human T-cell lymphomas overexpressing the Hodgkin's disease antigen, CD30. Here, we used proteomics as a basis for modeling the molecular functions and biological processes involved in MDV-induced lymphomagenesis. Proteins were extracted from an MDV-transformed cell line and were then identified using 2-D LC-ESI-MS/MS. From the resulting 3870 cellular and 21 MDV proteins we confirm the existence of 3150 "predicted" and 12 "hypothetical" chicken proteins. The UA-01 proteome is proliferative, differentiated, angiogenic, pro-metastatic and pro-immune-escape but anti-programmed cell death, -anergy, -quiescence and -senescence and is consistent with a cancer phenotype. In particular, the pro-metastatic integrin signaling pathway and the ERK/MAPK signaling pathways were the two predominant signaling pathways represented. The cytokines, cytokine receptors, and their related proteins suggest that UA-01 has a regulatory T-cell phenotype. en_US
dc.language.iso en en_US
dc.publisher Proteomics en_US
dc.subject Research Subject Categories::NATURAL SCIENCES en_US
dc.title Modeling the proteome of a Marek's disease transformed cell line: a natural animal model for CD30 overexpressing lymphomas. en_US
dc.type Article en_US


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