xmlui.dri2xhtml.structural.head-subtitle

Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes

Show simple item record

dc.contributor.author Naessens, Jan
dc.contributor.author Mwangi, Duncan M.
dc.contributor.author Buza, Joram
dc.contributor.author Moloo, Shamshudeen K.
dc.date.accessioned 2019-10-08T07:23:05Z
dc.date.available 2019-10-08T07:23:05Z
dc.date.issued 2003
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/468
dc.description Research Article published by Blackwell Publishing Ltd en_US
dc.description.abstract The first visible response in livestock to the bite of a trypanosomeinfected tsetse fly is the formation of a localized skin reaction, also known as a chancre. This is an inflammatory response in the skin associated with swelling and an influx of cells. It is thought to be associated with an acquired immune response to the injected metacyclic trypanosomes. In this study, we examined the role of T lymphocytes in the development of the inflammatory response, by depleting cattle of T cell subpopulations and monitoring the development of chancres. Depletion of CD4 cells, but not CD8 cells, resulted in a significant reduction in chancre formation, confirming that an acquired response mediates the inflammatory response. In addition, it was established that the CD4 T cells mediate the generation of memory for immunity to a homologueous re-challenge. The inflammatory response in the skin did not affect further progress of the infection. en_US
dc.language.iso en en_US
dc.publisher Blackwell Science Ltd en_US
dc.subject CD4 T lymphocyte en_US
dc.subject trypanosome en_US
dc.title Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search Our NM-AIST IR


Browse NM-AIST IR

My NM-AIST IR Account

Statistics