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The neoplastically transformed (CD30hi) Marek’s disease lymphoma cell phenotype most closely resembles T-regulatory cells

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dc.contributor.author Shack, L. A.
dc.contributor.author Buza, J. J.
dc.contributor.author Burgess, S. C.
dc.date.accessioned 2019-10-07T10:29:56Z
dc.date.available 2019-10-07T10:29:56Z
dc.date.issued 2008-02-07
dc.identifier.uri https://doi 10.1007/s00262-008-0460-2
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/456
dc.description Research Article published by Springer-Verlag en_US
dc.description.abstract Introduction Marek’s disease (MD), a herpesvirus-induced lymphoma of chickens is a unique natural model of CD30- overexpressing (CD30hi) lymphoma. We have previously proposed that the CD30hi neoplastically transformed CD4+ T cells in MD lymphomas have a phenotype antagonistic to cell mediated immunity. Here were test the hypothesis that the CD30hi neoplastically transformed MD lymphoma cells have a phenotype more closely resembling T-helper (Th)-2 or regulatory T (T-reg) cells. Materials and methods We separated ex vivo-derived CD30hi, from the CD30lo/¡ (non-transformed), MD lymphoma cells and then quantiWed the relative amounts of mRNA and proteins for cytokines and other genes that deWne CD4+ Th-1, Th-2 or T-reg phenotypes. Results and discussion Gene Ontology-based modeling of our data shows that the CD30hi MD lymphoma cells having a phenotype more similar to T-reg. Sequences that could be bound by the MD virus putative oncoprotein Meq in each of these genes’ promoters suggests that the MD herpesvirus may play a direct role in maintaining this T-reg-like phenotype. en_US
dc.language.iso en en_US
dc.publisher Springer-Verlag en_US
dc.subject Regulatory T cell en_US
dc.subject Gene Ontology en_US
dc.subject Systems biology en_US
dc.subject Animal model en_US
dc.title The neoplastically transformed (CD30hi) Marek’s disease lymphoma cell phenotype most closely resembles T-regulatory cells en_US
dc.type Article en_US


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