xmlui.dri2xhtml.structural.head-subtitle

Blood cytokine responses to early secreted protein antigen-6/culture filtrate protein-10 tuberculosis antigens 2 months after antituberculosis treatment among patients with drug-susceptible pulmonary tuberculosis.

Show simple item record

dc.contributor.author Mvungi, Happiness Cornel
dc.contributor.author Mbelele, Peter Masunga
dc.contributor.author Buza, Joram
dc.contributor.author Mpagama, Stellah George
dc.contributor.author Sauli, Elingarami
dc.date.accessioned 2019-07-25T11:38:54Z
dc.date.available 2019-07-25T11:38:54Z
dc.date.issued 2019-03-12
dc.identifier.other 30860180
dc.identifier.uri http://www.ijmyco.org/text.asp?2019/8/1/53/253964
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/382
dc.description Research Article published by Wolters Kluwer - Medknow Volume 8 | Issue 1 | January‑March 2019 en_US
dc.description.abstract Background: Human tuberculosis is a chronic inflammatory disease caused by mycobacterium tuberculosis. Pulmonary tuberculosis is the result of the failure of host immune system to control mycobacterium tuberculosis. The aim of the study was to asses the changes of the cytokines in active pulmonary tuberculosis patients before and after the use of anti-TB therapy. Methods: Multiple cytokine responses in active tuberculosis (TB) patients were investigated in this study following anti-TB drug therapy after 2 months. Ninety-six participants with pulmonary TB were engaged in the study between May 2018 and October 2018. Samples of blood were taken early before treatment at 0 and 2 months after using anti-TB therapy. The levels of interferon-gamma (IFN)-γ, interleukin-4 (IL-4), IL-6, IL-10, and tumor necrosis factor (TNF)-α in whole blood plasma collected from the QuantiFERON-TB Gold Plus were measured. Results: Compared with baseline levels, TNF-α, IL6 and IL10 were significantly lower following treatment whereas the IFN-γ and IL-4 increased significantly after treatment. The responses of five cytokines varied significantly after treatment (P < 0.0001) where IFN-γ was highest compared to other cytokines with 123.6%, AUC=0.757 and P < 0001, TNF-α AUC: 0.529 and P = 0.743, IL-4 AUC:0.557 and P = 0.514, IL-6 AUC:0.629 and P = 0.047, IL-10 AUC:0.549 and P = 0.581. Conclusion: It is concluded that changes of cytokines that observed during the treatment of TB patients play a very important role in monitoring pulmonary TB and can be suitable biomarkers to assess the effectiveness of anti-TB therapy in patients with TB.
dc.language.iso en en_US
dc.publisher Wolters Kluwer - Medknow en_US
dc.subject Antituberculosis therapy en_US
dc.subject QuantiFERON-TB Gold Plus en_US
dc.subject Biomarkers en_US
dc.subject Cytokines en_US
dc.subject Pulmonary tuberculosis en_US
dc.title Blood cytokine responses to early secreted protein antigen-6/culture filtrate protein-10 tuberculosis antigens 2 months after antituberculosis treatment among patients with drug-susceptible pulmonary tuberculosis. en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search Our NM-AIST IR


Browse NM-AIST IR

My NM-AIST IR Account

Statistics