Ki-67, p53 and BCL-2 Expressions and their Association with Clinical Histopathology of Breast Cancer among Women in Tanzania

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dc.contributor.author Mansouri, Hidaya
dc.contributor.author Mnango, Leah F.
dc.contributor.author Magorosa, Erick P.
dc.contributor.author Sauli, Elingarami
dc.contributor.author Mpolya, Emmanuel A.
dc.date.accessioned 2019-07-12T05:00:48Z
dc.date.available 2019-07-12T05:00:48Z
dc.date.issued 2019-07-09
dc.identifier.uri https://doi.org/10.1038/s41598-019-46184-x
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/362
dc.description Published by Scientific Reports en_US
dc.description.abstract This study associated Ki-67, p53, and BCL-2 markers with clinical histopathological (CH) features using currently available limited data on these markers in Tanzania. Retrospective chart review study was conducted among females with confrmed breast cancer (BC) at Muhimbili National Hospital in Tanzania between 2016 and 2017. Inclusion criteria were met by 76 patients with a mean age of 51.32±14.28 years. Of these, 86.4% were stage III and IV, whereas 83.5% cases had grade 2 and grade 3. Upon immunostaining, 85.5% and 57.9% were Ki-67 and BCL-2 positive respectively. Log-linear analysis showed no statistically signifcant association among biomarkers expression and CH features. However, multinomial linear regression showed higher possibility for association between high expression of Ki-67, low expression of p53 and high expression of BCL-2 with age, grade, stage and tumor (T) stage. BCL-2 was positively correlated with Ki-67 expression contrary to p53, which was negatively correlated with BCL-2. Conclusively, there is evidence of correlation between the studied markers with CH features. However, studies with larger sample sizes will likely reveal signifcant associations that will validate the role of these markers as tools for evaluating treatment response in individualized therapeutic schemes in Tanzania. en_US
dc.language.iso en_US en_US
dc.publisher Scientific Reports en_US
dc.subject Research Subject Categories::NATURAL SCIENCES en_US
dc.title Ki-67, p53 and BCL-2 Expressions and their Association with Clinical Histopathology of Breast Cancer among Women in Tanzania en_US
dc.type Article en_US

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