Evaluation of Antibacterial Activity of Five Selected Medicinal Plants in Tanzania against Gram Negative Bacteria

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dc.contributor.author Kowero, Elibariki Eliangilisa
dc.contributor.author Leweri, Cecilia
dc.contributor.author Chacha, Musa
dc.date.accessioned 2019-05-22T08:46:58Z
dc.date.available 2019-05-22T08:46:58Z
dc.date.issued 2016-01-04
dc.identifier.issn 2231-0894
dc.identifier.uri DOI: 10.9734/EJMP/2016/22695
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/145
dc.description Research Article published by European Journal of Medicinal Plants en_US
dc.description.abstract Aims: To evaluate antibacterial activity from five selected medicinal plants namely Embelia schimperi, Maerua decumbens, Ocimum gratissimum, Conyza floribunda and Plectranthus barbatus used for the management of bacterial infections in Tanzania. Study Design: In vitro antibacterial activity was carried out by using 96 well microplates method. Place and Duration of Study: The samples were collected in three region of Tanzania namely Kilimanjaro, Arusha and Dodoma. Extraction and antibacterial assay was conducted at School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, Tanzania, between February and June 2015. Methodology: Minimum Inhibitory Concentration (MIC) of plants extracts against the tested Gram negative bacteria was determined by using 96 well microdilution methods. Results: Plant extracts exhibited antibacterial activity with MIC range of 1.56 mg/mL to >25 mg/mL. About 36% (8) of extracts, out of 22 extracts demonstrated antibacterial activity with MIC of 1.56 mg/mL against K. oxytoca, P. aeruginosa, P. mirabilis, E. coli and S. typhii. The inter-species activity comparison indicated that antibacterial activity of the evaluated plant species are in order of Conzya floribunda ˃ Plectranthus barbatus > Maerua decumbens > Embelia schimperi and Ocimum gratissimum. The Conyza floribunda extracts exhibited a narrow range antibacterial activity (MIC of 1.56 to 6.25 mg/mL) compared to the rest of plant species in this study. Conclusion: The highest inhibitory effects exhibited by C. floribunda root chloroform, O. gratissimum leaf methanolic and O. gratissimum flower ethyl acetate extracts against at least two bacteria strains validates the traditional uses of these plants for the management of infections caused by Gram negative bacteria. en_US
dc.language.iso en_US en_US
dc.publisher European Journal of Medicinal Plants en_US
dc.subject Gram negative en_US
dc.subject Medicinal plants en_US
dc.subject Embelia schimperi en_US
dc.subject Ocimum gratissium en_US
dc.subject Conyza floribunda en_US
dc.title Evaluation of Antibacterial Activity of Five Selected Medicinal Plants in Tanzania against Gram Negative Bacteria en_US
dc.type Article en_US

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