Browsing by Author "Gathirwa, Jeremiah"
Now showing items 1-9 of 9
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Antimalarial potential and phytochemical composition of fractions of Lippia kituiensis Vatke (Verbenaceae) growing in Northern Tanzania
Ng’etich, Japheth; Swai, Hulda; Njokah, Joseph; Wachira, Sabina; Koech, Lilian; Gathirwa, Jeremiah (Journal of Medicinal Plants Research, 2020-08-31)Despite past decades of steady advances in the fight against Malaria, statistics show that the disease is still a threat to human health. Previous successes in the development of antimalarial drugs from medicinal plants ... -
Chitosan-coated liposomes of Carrisa spinarum extract: synthesis, analysis and anti-pneumococcal potency
Rubaka, Clarence; Gathirwa, Jeremiah; Malebo, Hamisi; Swai, Hulda; Sibuyi, Nicole; Hilonga, Askwar; Dube, Admire (ICE Publishing, 2023-02-16)In the present study, a chitosan (CS)-coated liposome (LipCsP-Chitosan) nanocarrier was fabricated for the delivery of Carissa spinarum (CsP) polyphenols to improve bioavailability and anti-pneumococcal potential against ... -
Development and Characterization of Nanovesicles Containing Phenolic Compounds of Carissa spinarum: Encapsulation, Release Kinetics, Antimicrobial Activity and Mathematical Modeling
Rubaka, Clarence; Gathirwa, Jeremiah; Malebo, Hamisi; Swai, Hulda; Hilonga, Askwar (Trans Tech Publications Ltd, 2023-05)The aim of this study was to develop and characterize a delivery system for polyphenols from an extract of Carissa spinarum leaves, based on liposomes. Liposomes loaded with Carissa spinarum polyphenols (nanoliposomal CsP) ... -
Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles.
Omwoyo, Wesley; Melariri, Paula; Gathirwa, Jeremiah; Oloo, Florence; Mahanga, Geoffrey; Kalombo, Lonji; Ogutu, Bernhards; Swai, Hulda (Elsevier, 2016-04-01)Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA ... -
Formulation, Optimization, and Evaluation of Moringa oleifera Leaf Polyphenol-Loaded Phytosome Delivery System against Breast Cancer Cell Lines
Wanjiru, Jecinta; Gathirwa, Jeremiah; Sauli, Elingarami; Swai, Hulda (MDPI, 2022-07-11)Moringa oleifera leaf polyphenols (Mopp) were encapsulated with phytosomes to enhance their efficacy on 4T1 cancer cell lines. The Mopp were extracted via microwave-assisted extraction. Moringa oleifera polyphenol-loaded ... -
In vitro antiproliferative potential of Annona senegalensis Pers. and Allophylus africanus P Beauv. plant extracts against selected cancer cell lines
Biseko, Emiliana Zacharia; Swai, Hulda; Mbugua, Regina Wachuka; Ndung’u, Jecinta Wanjiru; Chepng’etich, Jean; Gathirwa, Jeremiah (Journal of Medicinal Plants Research, 2019-07-10)The medicinal plants Annona senegalensis Pers. and Allophylus africanus P Beauv. are used in Tanzania traditional medicine for the treatment of cancer. However, there is no scientific documentation on their therapeutic ... -
In vitro antiproliferative potential of crude extracts from Carica papaya L. (Caricaceae) black seeds against prostate cancer cell lines'
Kateihwa, Benson; Swai, Hulda; Gathirwa, Jeremiah; Sauli, Elingarami (American Journals, 2022-04-30)Black seeds from papaya plants are utilized as traditional medicine in African and Asian cultures to improve the functioning of the male reproductive system and management of prostate cancer. This study analyzed the ... -
Inorganic Nanocarriers: Surface Functionalization, Delivery Utility for Natural Therapeutics - A Review
Rubaka, Clarence; Gathirwa, Jeremiah; Malebo, Hamisi; Swai, Hulda; Hilonga, Askwar (Scientific.Net, 2022-08)Inorganic nanocarriers for a decade have increased interest in nanotechnology research platform as versatile drug delivery materials. The utility of the inorganic nanocarriers for delivery of therapeutic agents is attributed ... -
Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles
Omwoyo, Wesley; Ogutu, Bernhards; Oloo, Florence; Swai, Hulda; Kalombo, Lonji; Melariri, Paula; Mahanga, Geoffrey; Gathirwa, Jeremiah (Dovepress, 2014-08-11)Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- ...